Tracey A Rouault Selected Research

sulofenur (ISCU)

12/2016	Use of antisense oligonucleotides to correct the splicing error in ISCU myopathy patient cell lines.
11/2012	Tissue specificity of a human mitochondrial disease: differentiation-enhanced mis-splicing of the Fe-S scaffold gene ISCU renders patient cells more sensitive to oxidative stress in ISCU myopathy.
3/2012	Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease.
6/2010	Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease.
1/2010	Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.
8/2008	Iron-sulfur cluster biogenesis and human disease.
3/2008	Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.

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Tracey A Rouault Research Topics

Disease

16	Iron Overload 01/2019 - 01/2002
15	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2022 - 01/2002
15	Iron Deficiencies 01/2022 - 10/2004
15	Anemia 11/2018 - 11/2003
10	Friedreich Ataxia (Friedreich's Ataxia) 01/2018 - 04/2005
8	Hypoxia (Hypoxemia) 10/2021 - 09/2011
8	Neoplasms (Cancer) 01/2021 - 09/2011
7	Muscular Diseases (Myopathy) 12/2016 - 03/2008
6	Kidney Neoplasms (Kidney Cancer) 01/2021 - 09/2011
6	Sideroblastic Anemia 01/2018 - 08/2008
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 11/2012
5	Renal Cell Carcinoma (Grawitz Tumor) 01/2021 - 09/2011
5	Hemolysis 11/2018 - 12/2010
4	Inflammation (Inflammations) 01/2021 - 09/2010
4	Pulmonary Hypertension 01/2021 - 02/2013
4	Polycythemia (Erythrocytosis) 01/2021 - 02/2013
3	Disease Progression 01/2021 - 06/2003
3	Leiomyomatosis 01/2021 - 09/2011
3	Ataxia (Dyssynergia) 01/2019 - 04/2005
2	Dystonia (Limb Dystonia) 01/2022 - 08/2013
2	Multiple Mitochondrial Dysfunctions Syndrome 11/2020 - 03/2012
2	Erythropoietic Protoporphyria 01/2019 - 08/2005
2	Hemorrhage 09/2015 - 02/2013
2	Starvation 01/2014 - 01/2011
1	Nervous System Diseases (Neurological Disorders) 04/2022
1	Seizures (Absence Seizure) 01/2022
1	COVID-19 01/2021
1	Fibrosis (Cirrhosis) 01/2021
1	Neoplasm Metastasis (Metastasis) 01/2021
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2021
1	Multiple Sclerosis 10/2019
1	Demyelinating Diseases (Demyelinating Disease) 10/2019
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/2019
1	Movement Disorders (Movement Disorder) 01/2019
1	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 01/2019
1	X-linked sideroblastic anemia 01/2019
1	Hemolytic Anemia 11/2018
1	Infections 01/2018
1	Malaria 01/2018
1	Genomic Instability 01/2018
1	Respiratory Insufficiency (Respiratory Failure) 01/2018
1	Splenomegaly 01/2018
1	Leukoencephalopathies 02/2016

Drug/Important Bio-Agent (IBA)

50	IronIBA 04/2022 - 01/2002
17	Proteins (Proteins, Gene)FDA Link 01/2018 - 01/2002
11	Ferritins (Ferritin)IBA 01/2018 - 05/2003
10	SulfurIBA 01/2021 - 03/2008
7	Iron-Regulatory Proteins (Iron-Responsive Element Binding Proteins)IBA 01/2019 - 03/2008
7	sulofenur (ISCU)IBA 12/2016 - 03/2008
6	Iron Regulatory Protein 2IBA 04/2022 - 05/2003
6	FrataxinIBA 02/2016 - 03/2008
5	Fumarate Hydratase (Fumarase)IBA 01/2021 - 09/2011
5	metal transporting protein 1 (ferroportin)IBA 11/2018 - 11/2003
4	HepcidinsIBA 10/2021 - 01/2018
4	Erythropoietin FDA Link 01/2021 - 07/2010
4	EnzymesIBA 01/2021 - 06/2010
4	Heme (Haem)IBA 01/2018 - 05/2010
4	Messenger RNA (mRNA)IBA 11/2012 - 03/2008
3	ElementsIBA 01/2022 - 05/2010
3	FumaratesIBA 01/2021 - 07/2013
3	Iron Regulatory Protein 1IBA 01/2021 - 05/2010
3	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2013
3	Glutamine (L-Glutamine)FDA Link 01/2020 - 01/2013
3	tempolIBA 01/2018 - 08/2008
3	Transferrin Receptors (Transferrin Receptor)IBA 01/2018 - 01/2011
3	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2016 - 03/2008
3	GlutaredoxinsIBA 06/2010 - 08/2008
3	Aconitate Hydratase (Aconitase)IBA 06/2010 - 03/2008
2	Endothelin-1 (Endothelin 1)IBA 01/2021 - 02/2013
2	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 02/2012
2	Hemoglobins (Hemoglobin)IBA 01/2018 - 12/2010
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 07/2013
2	Succinic Acid (Succinate)IBA 02/2016 - 01/2016
2	Heme Oxygenase-1IBA 08/2014 - 12/2010
2	Acetyl-CoA CarboxylaseIBA 07/2013 - 09/2011
2	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 07/2013 - 11/2012
2	AMP-Activated Protein KinasesIBA 07/2013 - 09/2011
2	protoporphyrin IXIBA 03/2006 - 08/2005
2	Transferrin (beta 2 Transferrin)IBA 08/2005 - 11/2003
1	belzutifanIBA 01/2021
1	Mitochondrial DNA (mtDNA)IBA 01/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	Hormones (Hormone)IBA 01/2021
1	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 01/2021
1	Carrier Proteins (Binding Protein)IBA 11/2020
1	Pyruvic Acid (Pyruvate)IBA 01/2020
1	Adenosine Triphosphate (ATP)IBA 01/2019
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2019
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2018
1	phenylhydrazine (phenylhydrazine hydrochloride)IBA 11/2018
1	Citric Acid (Citrate)FDA LinkGeneric 01/2018
1	Histidine (L-Histidine)FDA Link 01/2018
1	nitroxylIBA 01/2018
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2018
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2018
1	Dextrans (Dextran)FDA Link 01/2018
1	Antisense OligonucleotidesIBA 12/2016
1	Riboflavin (Vitamin B2)FDA LinkGeneric 02/2016

Therapy/Procedure

4	Therapeutics 01/2021 - 07/2013
1	Injections 01/2018